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A Procalcitonin-Based Algorithm to Guide Antibiotic Therapy in Secondary Peritonitis following Emergency Surgery: A Prospective Study with Propensity Score Matching Analysis

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  • Ting-Shuo Huang
  • Shie-Shian Huang
  • Yu-Chiau Shyu
  • Chun-Hui Lee
  • Shyh-Chuan Jwo
  • Pei-Jer Chen
  • Huang-Yang Chen

Abstract

Background: Procalcitonin (PCT)-based algorithms have been used to guide antibiotic therapy in several clinical settings. However, evidence supporting PCT-based algorithms for secondary peritonitis after emergency surgery is scanty. In this study, we aimed to investigate whether a PCT-based algorithm could safely reduce antibiotic exposure in this population. Methods/Principal Findings: From April 2012 to March 2013, patients that had secondary peritonitis diagnosed at the emergency department and underwent emergency surgery were screened for eligibility. PCT levels were obtained pre-operatively, on post-operative days 1, 3, 5, and 7, and on subsequent days if needed. Antibiotics were discontinued if PCT was

Suggested Citation

  • Ting-Shuo Huang & Shie-Shian Huang & Yu-Chiau Shyu & Chun-Hui Lee & Shyh-Chuan Jwo & Pei-Jer Chen & Huang-Yang Chen, 2014. "A Procalcitonin-Based Algorithm to Guide Antibiotic Therapy in Secondary Peritonitis following Emergency Surgery: A Prospective Study with Propensity Score Matching Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
    • Handle: RePEc:plo:pone00:0090539
    DOI: 10.1371/journal.pone.0090539
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