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Association between RANTES Gene Polymorphisms and Asthma: A Meta-Analysis

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  • Dan Wen
  • Xin Du
  • Shao-Ping Nie
  • Jian-Zeng Dong
  • Chang-Sheng Ma

Abstract

Background: A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (−403 G/A, −28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations. Objective: The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis. Methods: Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated. Results: Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of −403 G/A, as well as 3311 cases and 4031 controls of −28C/G in this meta-analysis. The overall ORs and 95% CIs of −403 G/A were 1.19, 1.06–1.33 (P

Suggested Citation

  • Dan Wen & Xin Du & Shao-Ping Nie & Jian-Zeng Dong & Chang-Sheng Ma, 2014. "Association between RANTES Gene Polymorphisms and Asthma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-6, June.
    • Handle: RePEc:plo:pone00:0090460
    DOI: 10.1371/journal.pone.0090460
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