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Association between 9p21 Genomic Markers and Ischemic Stroke Risk: Evidence Based on 21 Studies

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  • Xiaoqing Ni
  • Jiawei Zhang

Abstract

Epidemiological studies indicate a genetic contribution to ischemic stroke risk, but specific genetic variants remain unknown. Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21 (rs10757278 and proxy SNPs). Given that stroke is a common complication after myocardial infarction, several validation studies have been conducted among various ethnic populations to investigate if the same loci was associated with ischemic stroke (IS), but the results have been inconsistent. To investigate this inconsistency and derive a more precise estimation of the relationship, a meta-analysis of 34,128 cases and 153,428 controls from 21 studies was performed. Potential sources of heterogeneity including ethnicity, sample size, control source and ischemic stroke subtypes were also assessed. Overall, the summary odds ratio of IS was 1.11 (95% CI: 1.07–1.15, P

Suggested Citation

  • Xiaoqing Ni & Jiawei Zhang, 2014. "Association between 9p21 Genomic Markers and Ischemic Stroke Risk: Evidence Based on 21 Studies," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0090255
    DOI: 10.1371/journal.pone.0090255
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