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Dynamic Changes in Serum 25-Hydroxyvitamin D during Pregnancy and Lack of Effect on Thyroid Parameters

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  • Yuhang Zhao
  • Wei Miao
  • Chenyang Li
  • Xiaohui Yu
  • Zhongyan Shan
  • Haixia Guan
  • Weiping Teng

Abstract

Background & Aims: To explore vitamin D status and its dynamic changes during pregnancy in women living in Northeast China. The association between 25-hydroxyvitamin D and serum calcium, phosphate and parathyroid hormone was studied. Because vitamin D deficiency or thyroid dysfunction/autoimmunity during pregnancy may lead to similar adverse events, the relationship between 25-hydroxyvitamin D and thyroid parameters was investigated. Methods: Serum samples of 50 women (aged 22 to 36 years) were selected retrospectively. The samples were collected at gestational 8 weeks ±3 days, 20 weeks ±3 days and 32 weeks ±3 days for measurement of 25-hydroxyvitamin D, calcium, phosphate, parathyroid hormone, and thyroid parameters. Results: The median 25-hydroxyvitamin D levels were 28.29, 39.23 and 40.03 nmol/L, respectively, from the first to the third trimester. The 25-hydroxyvitamin D concentration during the first trimester was significantly lower than the next two trimesters (p

Suggested Citation

  • Yuhang Zhao & Wei Miao & Chenyang Li & Xiaohui Yu & Zhongyan Shan & Haixia Guan & Weiping Teng, 2014. "Dynamic Changes in Serum 25-Hydroxyvitamin D during Pregnancy and Lack of Effect on Thyroid Parameters," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
    • Handle: RePEc:plo:pone00:0090161
    DOI: 10.1371/journal.pone.0090161
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