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Macrolide Therapy in Adults and Children with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and Meta-Analysis

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Listed:
  • Yong-hua Gao
  • Wei-jie Guan
  • Gang Xu
  • Yan Tang
  • Yang Gao
  • Zhi-ya Lin
  • Zhi-min Lin
  • Nan-shan Zhong
  • Rong-chang Chen

Abstract

Background: A systematic review and meta-analysis was conducted to evaluate the efficacy and safety of macrolide therapy in adults and children with bronchiectasis. Methods: We searched the PUBMED, EMBASE, CENTRAL databases to identify relevant studies. Two reviewers evaluated the studies and extracted data independently. The primary outcome was the number of bronchiectasis exacerbations. Secondary outcomes included exacerbation-related admissions, quality of life (QoL), spirometry, 6-minute walk test (6MWT) and adverse events. Results: Nine eligible trials with 559 participants were included. Six were conducted on adults, and the remaining on children. Macrolide therapy significantly reduced the number of patients experiencing one or more exacerbation in adults [risk ratio (RR) = 0.59; 95% CI, 0.40 to 0.86; P = 0.006; I2 = 65%] and children [RR = 0.86; 95% CI, 0.75–0.99; P = 0.04; I2 = 0%], but not the number of patients with admissions for exacerbation. Macrolide therapy was also associated with reduced frequency of exacerbations in adults (RR = 0.42; 95% CI, 0.29 to 0.61; P

Suggested Citation

  • Yong-hua Gao & Wei-jie Guan & Gang Xu & Yan Tang & Yang Gao & Zhi-ya Lin & Zhi-min Lin & Nan-shan Zhong & Rong-chang Chen, 2014. "Macrolide Therapy in Adults and Children with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0090047
    DOI: 10.1371/journal.pone.0090047
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