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BRAF-V600 Mutations Have No Prognostic Impact in Stage IV Melanoma Patients Treated with Monochemotherapy

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Listed:
  • Diana Meckbach
  • Ulrike Keim
  • Sabina Richter
  • Ulrike Leiter
  • Thomas K Eigentler
  • Jürgen Bauer
  • Annette Pflugfelder
  • Petra Büttner
  • Claus Garbe
  • Benjamin Weide

Abstract

Background: The impact of BRAF tumor mutations on the natural course of disease of melanoma patients is controversial. Patients and Methods: We analyzed the mutational status and overall survival of 215 patients receiving treatment with dacarbazine or temozolomide. All patients who started first-line treatment at our institution between 2000 and 2010 were included to prevent selection and bias due to thereafter arising therapeutic options. Results: No patient received BRAF- or MEK-inhibitors during follow-up. Survival was associated with the pattern of visceral involvement, the presence of brain metastases and the serum lactate dehydrogenase level (all p

Suggested Citation

  • Diana Meckbach & Ulrike Keim & Sabina Richter & Ulrike Leiter & Thomas K Eigentler & Jürgen Bauer & Annette Pflugfelder & Petra Büttner & Claus Garbe & Benjamin Weide, 2014. "BRAF-V600 Mutations Have No Prognostic Impact in Stage IV Melanoma Patients Treated with Monochemotherapy," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0089218
    DOI: 10.1371/journal.pone.0089218
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