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Th1 Response and Systemic Treg Deficiency in Inclusion Body Myositis

Author

Listed:
  • Yves Allenbach
  • Wahiba Chaara
  • Michelle Rosenzwajg
  • Adrien Six
  • Nicolas Prevel
  • Federico Mingozzi
  • Julia Wanschitz
  • Lucile Musset
  • Jean-Luc Charuel
  • Bruno Eymard
  • Benoit Salomon
  • Charles Duyckaerts
  • Thierry Maisonobe
  • Odile Dubourg
  • Serge Herson
  • David Klatzmann
  • Olivier Benveniste

Abstract

Objective: Sporadic inclusion body myositis (sIBM), the most frequent myositis in elderly patients, is characterized by the presence muscle inflammation and degeneration. We aimed at characterizing immune responses and regulatory T cells, considered key players in the maintenance of peripheral immune tolerance, in sIBM. Methods: Serum and muscle tissue levels of 25 cytokines and phenotype of circulating immune cells were measured in 22 sIBM patients and compared with 22 healthy subjects. Cytokine data were analysed by unsupervised hierarchical clustering and principal components analysis. Results: Compared to healthy controls, sIBM patients had increased levels of Th-1 cytokines and chemokines such as IL-12 (261±138 pg/mL vs. 88±19 pg/mL; p

Suggested Citation

  • Yves Allenbach & Wahiba Chaara & Michelle Rosenzwajg & Adrien Six & Nicolas Prevel & Federico Mingozzi & Julia Wanschitz & Lucile Musset & Jean-Luc Charuel & Bruno Eymard & Benoit Salomon & Charles Du, 2014. "Th1 Response and Systemic Treg Deficiency in Inclusion Body Myositis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0088788
    DOI: 10.1371/journal.pone.0088788
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