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Predictive Value of Updating Framingham Risk Scores with Novel Risk Markers in the U.S. General Population

Author

Listed:
  • Bart S Ferket
  • Bob J H van Kempen
  • M G Myriam Hunink
  • Isha Agarwal
  • Maryam Kavousi
  • Oscar H Franco
  • Ewout W Steyerberg
  • Wendy Max
  • Kirsten E Fleischmann

Abstract

Background: According to population-based cohort studies CT coronary calcium score (CTCS), carotid intima-media thickness (cIMT), high-sensitivity C- reactive protein (CRP), and ankle-brachial index (ABI) are promising novel risk markers for improving cardiovascular risk assessment. Their impact in the U.S. general population is however uncertain. Our aim was to estimate the predictive value of four novel cardiovascular risk markers for the U.S. general population. Methods and Findings: Risk profiles, CRP and ABI data of 3,736 asymptomatic subjects aged 40 or older from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 exam were used along with predicted CTCS and cIMT values. For each subject, we calculated 10-year cardiovascular risks with and without each risk marker. Event rates adjusted for competing risks were obtained by microsimulation. We assessed the impact of updated 10-year risk scores by reclassification and C-statistics. In the study population (mean age 56±11 years, 48% male), 70% (80%) were at low (

Suggested Citation

  • Bart S Ferket & Bob J H van Kempen & M G Myriam Hunink & Isha Agarwal & Maryam Kavousi & Oscar H Franco & Ewout W Steyerberg & Wendy Max & Kirsten E Fleischmann, 2014. "Predictive Value of Updating Framingham Risk Scores with Novel Risk Markers in the U.S. General Population," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0088312
    DOI: 10.1371/journal.pone.0088312
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    Cited by:

    1. Madhu Mazumdar & Jashvant V. Poeran & Bart S. Ferket & Nicole Zubizarreta & Parul Agarwal & Ksenia Gorbenko & Catherine K. Craven & Xiaobo (Tony) Zhong & Alan J. Moskowitz & Annetine C. Gelijns & Davi, 2021. "Developing an Institute for Health Care Delivery Science: successes, challenges, and solutions in the first five years," Health Care Management Science, Springer, vol. 24(1), pages 234-243, March.

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