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Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis

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  • Jie Chen
  • Jia Liu
  • Wei-Hai Xu
  • Ren Xu
  • Bo Hou
  • Li-Ying Cui
  • Shan Gao

Abstract

Purpose: We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. Methods: Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver. Results: Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery = 17.76±8.21%/s, phase = 26.93±15.67°, and CVR = 1.53±0.84%/mmHg, respectively) were significantly different (p

Suggested Citation

  • Jie Chen & Jia Liu & Wei-Hai Xu & Ren Xu & Bo Hou & Li-Ying Cui & Shan Gao, 2014. "Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-6, February.
    • Handle: RePEc:plo:pone00:0088232
    DOI: 10.1371/journal.pone.0088232
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