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Seven Functional Polymorphisms in the CETP Gene and Myocardial Infarction Risk: A Meta-Analysis and Meta-Regression

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  • Qi Wang
  • Shao-Bo Zhou
  • Li-Jie Wang
  • Ming-Ming Lei
  • Yong Wang
  • Chi Miao
  • Yuan-Zhe Jin

Abstract

Objective: This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk. Method: The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before March 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Results: Nine case-control studies with a total 8,623 MI cases and 8,564 healthy subjects met the inclusion criteria. The results of our meta-analysis suggested that CETP rs708272 (C>T) polymorphism might be correlated with an increased risk of MI, especially among Caucasians. Furthermore, we observed that CETP rs1800775 (C>A) polymorphism might increase the risk of MI. Nevertheless, no similar findings were found for CETP rs5882 (A>G), rs2303790 (A>G), rs1800776 (C>A), rs12149545 (G>A), and rs4783961 (G>A) polymorphisms. Conclusion: The current meta-analysis suggests that CETP rs708272 (C>T) and rs1800775 (C>A) polymorphisms may contribute to MI susceptibility, especially among Caucasians. Thus, CETP rs708272 and rs1800775 polymorphisms may be promising and potential biomarkers for early diagnosis of MI.

Suggested Citation

  • Qi Wang & Shao-Bo Zhou & Li-Jie Wang & Ming-Ming Lei & Yong Wang & Chi Miao & Yuan-Zhe Jin, 2014. "Seven Functional Polymorphisms in the CETP Gene and Myocardial Infarction Risk: A Meta-Analysis and Meta-Regression," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0088118
    DOI: 10.1371/journal.pone.0088118
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    Cited by:

    1. Hong Xu & Haiqing Li & Jun Liu & Dan Zhu & Zhe Wang & Anqing Chen & Qiang Zhao, 2014. "Meta-Analysis of Apolipoprotein E Gene Polymorphism and Susceptibility of Myocardial Infarction," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-10, August.
    2. Yunzhong Yang & Tianhua Niu, 2018. "A meta-analysis of associations of LEPR Q223R and K109R polymorphisms with Type 2 diabetes risk," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-25, January.

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