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TNF -308 G/A Polymorphism and Risk of Acne Vulgaris: A Meta-Analysis

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  • Jian-Kang Yang
  • Wen-Juan Wu
  • Jue Qi
  • Li He
  • Ya-Ping Zhang

Abstract

Background: The -308 G/A polymorphism in the tumor necrosis factor (TNF) gene has been implicated in the risk of acne vulgaris, but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -308 G/A polymorphism and acne vulgaris risk. Methods: We searched in Pubmed, Embase, Web of Science and CNKI for studies evaluating the association between the -308 G/A gene polymorphism and acne vulgaris risk. Data were extracted and statistical analysis was performed using STATA 12.0 software. Results: A total of five publications involving 1553 subjects (728 acne vulgaris cases and 825 controls) were included in this meta-analysis. Combined analysis revealed a significant association between this polymorphism and acne vulgaris risk under recessive model (OR = 2.73, 95% CI: 1.37–5.44, p = 0.004 for AA vs. AG + GG). Subgroup analysis by ethnicity showed that the acne vulgaris risk associated with the -308 G/A gene polymorphism was significantly elevated among Caucasians under recessive model (OR = 2.34, 95% CI: 1.13–4.86, p = 0.023). Conclusion: This meta-analysis suggests that the -308 G/A polymorphism in the TNF gene contributes to acne vulgaris risk, especially in Caucasian populations. Further studies among different ethnicity populations are needed to validate these findings.

Suggested Citation

  • Jian-Kang Yang & Wen-Juan Wu & Jue Qi & Li He & Ya-Ping Zhang, 2014. "TNF -308 G/A Polymorphism and Risk of Acne Vulgaris: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-5, February.
    • Handle: RePEc:plo:pone00:0087806
    DOI: 10.1371/journal.pone.0087806
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