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Plasma YKL-40 in Patients with Metastatic Colorectal Cancer Treated with First Line Oxaliplatin-Based Regimen with or without Cetuximab: RESULTS from the NORDIC VII Study

Author

Listed:
  • Line S Tarpgaard
  • Tormod K Guren
  • Bengt Glimelius
  • Ib J Christensen
  • Per Pfeiffer
  • Elin H Kure
  • Halfdan Sorbye
  • Tone Ikdahl
  • Mette Yilmaz
  • Julia S Johansen
  • Kjell Magne Tveit

Abstract

Background: We aim to test the hypothesis that high plasma YKL-40 is associated with short progression-free survival (PFS) and overall survival (OS) in patients with metastatic colorectal cancer (mCRC) treated with first-line oxaliplatin and 5-flourouracil with or without cetuximab. Patients and Methods: A total of 566 patients in the NORDIC VII Study were randomized 1∶1∶1 to arm A (Nordic FLOX), arm B (Nordic FLOX + cetuximab), or arm C (Nordic FLOX + cetuximab for 16 weeks followed by cetuximab alone as maintenance therapy). Pretreatment plasma samples were available from 510 patients. Plasma YKL-40 was determined by ELISA and dichotomized according to the age-corrected 95% YKL-40 level in 3130 healthy subjects. Results: Pretreatment plasma YKL-40 was elevated in 204 patients (40%), and median YKL-40 was higher in patients with mCRC than in healthy subjects (age adjusted, P

Suggested Citation

  • Line S Tarpgaard & Tormod K Guren & Bengt Glimelius & Ib J Christensen & Per Pfeiffer & Elin H Kure & Halfdan Sorbye & Tone Ikdahl & Mette Yilmaz & Julia S Johansen & Kjell Magne Tveit, 2014. "Plasma YKL-40 in Patients with Metastatic Colorectal Cancer Treated with First Line Oxaliplatin-Based Regimen with or without Cetuximab: RESULTS from the NORDIC VII Study," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0087746
    DOI: 10.1371/journal.pone.0087746
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