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Prognostic Role of Pre-Treatment Serum AFP-L3% in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis

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  • Jiwen Cheng
  • Wanli Wang
  • Yingjun Zhang
  • Xi Liu
  • Muxing Li
  • Zheng Wu
  • Zhengwen Liu
  • Yi Lv
  • Bo Wang

Abstract

Background: Serum lens culinaris agglutinin-reactive fraction of α-fetoprotein (AFP-L3%) has been widely used for HCC diagnosis and follow-up surveillance as tumor serologic marker. However, the prognostic value of high pre-treatment serum AFP-L3% in patients with hepatocellular carcinoma (HCC) remains controversial. We therefore conduct a meta-analysis to assess the relationship between high pre-treatment serum AFP-L3% and clinical outcome of HCC. Methods: Eligible studies were identified through systematic literature searches. A meta-analysis of fifteen studies (4,465 patients) was carried out to evaluate the association between high pre-treatment serum AFP-L3% and overall survival (OS) and disease-free survival (DFS) in HCC patients. Sensitivity and subgroup analyses were also conducted in this meta-analysis. Results: Our analysis results showed that high pre-treatment serum AFP-L3% implied poor OS (HR: 1.65, 95%CI: 1.45–1.89 p

Suggested Citation

  • Jiwen Cheng & Wanli Wang & Yingjun Zhang & Xi Liu & Muxing Li & Zheng Wu & Zhengwen Liu & Yi Lv & Bo Wang, 2014. "Prognostic Role of Pre-Treatment Serum AFP-L3% in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0087011
    DOI: 10.1371/journal.pone.0087011
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