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TMPRSS2-ERG Expression Predicts Prostate Cancer Survival and Associates with Stromal Biomarkers

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  • Christina Hägglöf
  • Peter Hammarsten
  • Kerstin Strömvall
  • Lars Egevad
  • Andreas Josefsson
  • Pär Stattin
  • Torvald Granfors
  • Anders Bergh

Abstract

The TMPRSS2-ERG gene fusion is found in approximately half of all prostate cancers. The functional and prognostic significance of TMPRSS2-ERG is, however, not fully understood. Based on a historical watchful waiting cohort, an association between TMPRSS2-ERG, evaluated as positive immune staining, and shorter survival of prostate cancer patients was identified. Expression of ERG was also associated with clinical markers such as advanced tumor stage, high Gleason score, presence of metastasis and prognostic tumor cell markers such as high Ki67, pEGFR and pAkt. Novel associations between TMPRSS2-ERG and alterations in the tumor stroma, for example, increased vascular density, hyaluronan and PDGFRβ and decreased Caveolin-1, all known to be associated with an aggressive disease, were found. The present study suggests that the TMPRSS2-ERG fusion gene is associated with a more aggressive prostate cancer phenotype, supported by changes in the tumor stroma.

Suggested Citation

  • Christina Hägglöf & Peter Hammarsten & Kerstin Strömvall & Lars Egevad & Andreas Josefsson & Pär Stattin & Torvald Granfors & Anders Bergh, 2014. "TMPRSS2-ERG Expression Predicts Prostate Cancer Survival and Associates with Stromal Biomarkers," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-6, February.
    • Handle: RePEc:plo:pone00:0086824
    DOI: 10.1371/journal.pone.0086824
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