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Decreased Expression of PTPN12 Correlates with Tumor Recurrence and Poor Survival of Patients with Hepatocellular Carcinoma

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  • Rong-Zhen Luo
  • Pei-Qiang Cai
  • Mei Li
  • Jia Fu
  • Zhi-Yi Zhang
  • Jie-Wei Chen
  • Yun Cao
  • Jing-Ping Yun
  • Dan Xie
  • Mu-Yan Cai

Abstract

Background: Protein tyrosine phosphatase non-receptor type 12 (PTPN12), has been identified as a potent tumor suppressor in human cancers and a critical regulator of cell adhesion and migration. However, the PTPN12 expression and its prognostic significance in HCC have not been well elucidated. Methodology/Principal Findings: In this study, tissue microarray-based immunohistochemistry (IHC) was investigated in an HCC cohort with adjacent liver tissues as controls. The resulting data were analyzed using receiver operating characteristic curves, Spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression modeling. Our results showed that decreased expression of PTPN12 was more frequently observed in HCC tissues compared to the adjacent non-tumorous liver tissues. Further correlation analyses indicated that the decreased PTPN12 expression was closely correlated with tumor recurrence (P = 0.015). Univariate analysis showed a significant association between decreased expression of PTPN12 and adverse cancer-specific survival and recurrence-free survival (P

Suggested Citation

  • Rong-Zhen Luo & Pei-Qiang Cai & Mei Li & Jia Fu & Zhi-Yi Zhang & Jie-Wei Chen & Yun Cao & Jing-Ping Yun & Dan Xie & Mu-Yan Cai, 2014. "Decreased Expression of PTPN12 Correlates with Tumor Recurrence and Poor Survival of Patients with Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0085592
    DOI: 10.1371/journal.pone.0085592
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