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Identification of Novel Molecular Markers for Prognosis Estimation of Acute Myeloid Leukemia: Over-Expression of PDCD7, FIS1 and Ang2 May Indicate Poor Prognosis in Pretreatment Patients with Acute Myeloid Leukemia

Author

Listed:
  • Yiming Tian
  • Zoufang Huang
  • Zhixiang Wang
  • Changxin Yin
  • Lanlan Zhou
  • Lingxiu Zhang
  • Kaikai Huang
  • Hongsheng Zhou
  • Xuejie Jiang
  • Jinming Li
  • Libin Liao
  • Mo Yang
  • Fanyi Meng

Abstract

Numerous factors impact on the prognosis of acute myeloid leukemia (AML), among which molecular genetic abnormalities are developed increasingly, however, accurate prediction for newly diagnosed AML patients remains unsatisfied. For further improving the prognosis evaluation system, we investigated the transcripts levels of PDCD7, FIS1, FAM3A, CA6, APP, KLRF1, ATCAY, GGT5 and Ang2 in 97 AML patients and 30 non-malignant controls, and validated using the published microarray data from 225 cytogenetically normal AML (CN-AML) patients treated according to the German AMLCG-1999 protocol. Real-time quantitative polymerase chain reaction and western blot were carried out, and clinical data were collected and analyzed. High Ang2 and FIS1 expression discriminated the CR rate of AML patients (62.5% versus 82.9% for Ang2, P = 0.011; 61.4% versus 82.2% for FIS1, P = 0.029). In CN-AML, patients with high FIS1 expression were more likely to be resistant to two courses of induction (P = 0.035). Overall survival (OS) and relapse-free survival (RFS) were shorter in CN-AML patients with high PDCD7 expression (P

Suggested Citation

  • Yiming Tian & Zoufang Huang & Zhixiang Wang & Changxin Yin & Lanlan Zhou & Lingxiu Zhang & Kaikai Huang & Hongsheng Zhou & Xuejie Jiang & Jinming Li & Libin Liao & Mo Yang & Fanyi Meng, 2014. "Identification of Novel Molecular Markers for Prognosis Estimation of Acute Myeloid Leukemia: Over-Expression of PDCD7, FIS1 and Ang2 May Indicate Poor Prognosis in Pretreatment Patients with Acute My," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-6, January.
    • Handle: RePEc:plo:pone00:0084150
    DOI: 10.1371/journal.pone.0084150
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