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Clozapine Prescribing in a Canadian Outpatient Population

Author

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  • Silvia Alessi-Severini
  • Josee-Anne Le Dorze
  • David Nguyen
  • Patricia Honcharik
  • Michael Eleff

Abstract

Objective: Description of demographics of an outpatient population of clozapine users. Methods: Retrospective chart review study of an urban population diagnosed with schizophrenia. Assessment of therapeutic histories in relation to clinical practice guidelines. Results: Seventy-seven of the 467 patients were on clozapine therapy. Average patients’ age was 39.4 ± 11.8 years) and 68% were males. The majority of patients (68%) had tried 3 or more antipsychotics before switching to clozapine, 21% had tried two and 11% had tried one. Median length of therapy prior to clozapine initiation was 8.9 years in males and 7.7 years in females. Conclusion: Until 2010, the use of clozapine was often delayed and more than 2 antipsychotic medications were tried for relatively long periods of time before patients were switched to this effective agent.

Suggested Citation

  • Silvia Alessi-Severini & Josee-Anne Le Dorze & David Nguyen & Patricia Honcharik & Michael Eleff, 2013. "Clozapine Prescribing in a Canadian Outpatient Population," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    • Handle: RePEc:plo:pone00:0083539
    DOI: 10.1371/journal.pone.0083539
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