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Apolipoprotein E Gene Variants on the Risk of End Stage Renal Disease

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  • Cheng Xue
  • Wei Nie
  • Dan Tang
  • Lujiang Yi
  • Changlin Mei

Abstract

Objective: End-stage renal disease (ESRD) is a severe health concern over the world. Associations between apolipoprotein E (apoE) gene polymorphisms and the risk of ESRD remained inconclusive. This study aimed to investigate the association between apoE gene polymorphisms and ESRD susceptibility. Methods: Databases including PubMed, Embase, Web of Science and the Cochrane Library were searched to find relevant studies. Meta-analysis method was used synthesize the eligible studies. Results: Sixteen pertinent case-control studies which included 3510 cases and 13924 controls were analyzed. A significant association was found between ε2 allele and the ESRD risk (odds ratio (OR) = 1.30, 95% confidence interval (CI) 1.15–1.46, P

Suggested Citation

  • Cheng Xue & Wei Nie & Dan Tang & Lujiang Yi & Changlin Mei, 2013. "Apolipoprotein E Gene Variants on the Risk of End Stage Renal Disease," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    • Handle: RePEc:plo:pone00:0083367
    DOI: 10.1371/journal.pone.0083367
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