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Utilizing Twins as Controls for Non-Twin Case-Materials in Genome Wide Association Studies

Author

Listed:
  • Andrea Ganna
  • Alfredo Ortega-Alonso
  • Aki Havulinna
  • Veikko Salomaa
  • Jaakko Kaprio
  • Nancy L Pedersen
  • Patrick F Sullivan
  • Erik Ingelsson
  • Christina M Hultman
  • Patrik K E Magnusson

Abstract

Twin registries around the globe have collected DNA samples from large numbers of monozygotic and dizygotic twins. The twin sample collections are frequently used as controls in disease-specific studies together with non-twins. This approach is unbiased under the hypothesis that twins and singletons are comparable in terms of allele frequencies; i.e. there are no genetic variants associated with being a twin per se. To test this hypothesis we performed a genome-wide association study comparing the allele frequency of 572,352 single nucleotide polymorphisms (SNPs) in 1,413 monozygotic (MZ) and 5,451 dizygotic (DZ) twins with 3,720 healthy singletons. Twins and singletons have been genotyped using the same platform. SNPs showing association with being a twin at P-value

Suggested Citation

  • Andrea Ganna & Alfredo Ortega-Alonso & Aki Havulinna & Veikko Salomaa & Jaakko Kaprio & Nancy L Pedersen & Patrick F Sullivan & Erik Ingelsson & Christina M Hultman & Patrik K E Magnusson, 2013. "Utilizing Twins as Controls for Non-Twin Case-Materials in Genome Wide Association Studies," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    • Handle: RePEc:plo:pone00:0083101
    DOI: 10.1371/journal.pone.0083101
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