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Dexmedetomidine as a Sedative Agent in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials

Author

Listed:
  • Laura Pasin
  • Teresa Greco
  • Paolo Feltracco
  • Annalisa Vittorio
  • Caetano Nigro Neto
  • Luca Cabrini
  • Giovanni Landoni
  • Gabriele Finco
  • Alberto Zangrillo

Abstract

Introduction: The effect of dexmedetomidine on length of intensive care unit (ICU) stay and time to extubation is still unclear. Materials and Methods: Pertinent studies were independently searched in BioMedCentral, PubMed, Embase, and the Cochrane Central Register of clinical trials (updated February first 2013). Randomized studies (dexmedetomidine versus any comparator) were included if including patients mechanically ventilated in an intensive care unit (ICU). Co-primary endpoints were the length of ICU stay (days) and time to extubation (hours). Secondary endpoint was mortality rate at the longest follow-up available. Results: The 27 included manuscripts (28 trials) randomized 3,648 patients (1,870 to dexmedetomidine and 1,778 to control). Overall analysis showed that the use of dexmedetomidine was associated with a significant reduction in length of ICU stay (weighted mean difference (WMD) = −0.79 [−1.17 to −0.40] days, p for effect

Suggested Citation

  • Laura Pasin & Teresa Greco & Paolo Feltracco & Annalisa Vittorio & Caetano Nigro Neto & Luca Cabrini & Giovanni Landoni & Gabriele Finco & Alberto Zangrillo, 2013. "Dexmedetomidine as a Sedative Agent in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0082913
    DOI: 10.1371/journal.pone.0082913
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