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A Meta-Analysis of Anti-Vascular Endothelial Growth Factor Remedy for Macular Edema Secondary to Central Retinal Vein Occlusion

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  • Peirong Huang
  • Wenquan Niu
  • Zhentian Ni
  • Renzuo Wang
  • Xiaodong Sun

Abstract

Background: Central retinal vein occlusion (CRVO) associates with severe vision outcome and no proven beneficial treatment. Our meta-analysis intended to appraise the efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) agents in macular edema (ME) following CRVO. Methods: Data were collected and analyzed by Review Manager 5.2.1. We employed a random-effects model to eliminate between-study heterogeneity. Nfs (called fail-safe number) was calculated to evaluate the publication bias. Results: We included 5 trials consisting 323 cases and 281 controls. Primary outcomes showed that overall comparison of anti-VEGF agents with placebo control yielded a 374% and 136% increased tendency for a gain of 15 letters or more on Early Treatment Diabetic Retinopathy Study (ETDRS) chart (95% confidence interval [95% CI]: 2.43–9.23; P

Suggested Citation

  • Peirong Huang & Wenquan Niu & Zhentian Ni & Renzuo Wang & Xiaodong Sun, 2013. "A Meta-Analysis of Anti-Vascular Endothelial Growth Factor Remedy for Macular Edema Secondary to Central Retinal Vein Occlusion," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0082454
    DOI: 10.1371/journal.pone.0082454
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