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B-Type Natriuretic Peptide and Prognosis of End-Stage Renal Disease: A Meta-Analysis

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  • Yun-Jiu Cheng
  • Feng-Juan Yao
  • Li-Juan Liu
  • Kai Tang
  • Xiao-Xiong Lin
  • Wei-Jie Li
  • Jing Zhang
  • Su-Hua Wu

Abstract

Background: The prognostic importance of B-type natriuretic peptide (BNP) or N-terminal pro BNP (NT-proBNP) in patients with end-stage renal disease (ESRD) remains controversial. Methodology/Principal Findings: We conducted an unrestricted search from the MEDLINE and EMBASE in all languages that were published between 1966 and Augest2013. Twenty-seven long-term prospective studies met our inclusion criterias. From the pooled analysis, elevated BNP/NT-proBNP was significantly associated with increased all cause mortality [odds ratio (OR), 3.85; 95% CI, 3.11 to 4.75], cardiovascular mortality (OR, 4.05; 95% CI, 2.53 to 6.84), and cardiovascular events (OR, 7.02; 95% CI, 2.21 to 22.33). The funnel plot showed no evidence of publication bias. The corresponding pooled positive and negative likelihood ratio for prediction of all cause mortality were 1.86 (95% CI, 1.66 to 2.08) and 0.48 (95% CI, 0.42 to 0.55), respectively. Conclusions/Significance: BNP/NT-proBNP is a promising prognostic tool to risk-stratify the patients with ESRD. Further investigations are warranted to elucidate the specific pathogenic mechanisms and the impact of other potential prognostic factors.

Suggested Citation

  • Yun-Jiu Cheng & Feng-Juan Yao & Li-Juan Liu & Kai Tang & Xiao-Xiong Lin & Wei-Jie Li & Jing Zhang & Su-Hua Wu, 2013. "B-Type Natriuretic Peptide and Prognosis of End-Stage Renal Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0079302
    DOI: 10.1371/journal.pone.0079302
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