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Combination of EGFR-TKIs and Chemotherapy as First-Line Therapy for Advanced NSCLC: A Meta-Analysis

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  • Pu-Yun OuYang
  • Zhen Su
  • Yan-Ping Mao
  • Wuguo Deng
  • Fang-Yun Xie

Abstract

The impact of combining epidermal growth factor receptor tyrosine kinase inhibitors (EGFR–TKIs) and chemotherapy as first-line therapy for patients with advanced non-small-cell lung cancer (NSCLC) remains controversial. Therefore, randomized trials that compared this combined regimen with chemotherapy or EGFR–TKIs monotherapy were included for this meta-analysis. We used published hazard ratios (HRs), if available, or derived treatment estimates from other survival data. Pooled estimates of treatment efficacy of the combined regimen in the entire unselected population and selected patients by EGFR-mutation status and smoking history were calculated. Eight trials eventually entered into this meta-analysis, including 4585 patients. Overall, the combined regimen significantly delayed disease progression (HR = 0.81, 95% CI 0.69–0.95, P = 0.01); subgroup analysis showed significantly higher progression free survival advantages in Asian patients (P

Suggested Citation

  • Pu-Yun OuYang & Zhen Su & Yan-Ping Mao & Wuguo Deng & Fang-Yun Xie, 2013. "Combination of EGFR-TKIs and Chemotherapy as First-Line Therapy for Advanced NSCLC: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0079000
    DOI: 10.1371/journal.pone.0079000
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