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The Association of Four Common Polymorphisms from Four Candidate Genes (COX-1, COX-2, ITGA2B, ITGA2) with Aspirin Insensitivity: A Meta-Analysis

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  • Zhiyuan Weng
  • Xiaobo Li
  • Yuqiong Li
  • Jinxiu Lin
  • Feng Peng
  • Wenquan Niu

Abstract

Objective: Evidence is mounting suggesting that a strong genetic component underlies aspirin insensitivity. To generate more information, we aimed to evaluate the association of four common polymorphisms (rs3842787, rs20417, rs201184269, rs1126643) from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity via a meta-analysis. Methods and Results: In total, there were 4 (353/595), 6 (344/698), 10 (588/878) and 7 (209/676) articles (patients/controls) qualified for rs3842787, rs20417, rs20118426 and rs1126643, respectively. The data were extracted in duplicate and analyzed by STATA software (Version 11.2). The risk estimate was expressed as odds ratio (OR) and 95% confidence interval (95% CI). Analyses of the full data set indicated significant associations of rs20417 (OR; 95% CI; P: 1.86; 1.44–2.41;

Suggested Citation

  • Zhiyuan Weng & Xiaobo Li & Yuqiong Li & Jinxiu Lin & Feng Peng & Wenquan Niu, 2013. "The Association of Four Common Polymorphisms from Four Candidate Genes (COX-1, COX-2, ITGA2B, ITGA2) with Aspirin Insensitivity: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0078093
    DOI: 10.1371/journal.pone.0078093
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