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Cytokine Profiles at Birth Predict Malaria Severity during Infancy

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  • Edward Kabyemela
  • Bronner P Gonçalves
  • D Rebecca Prevots
  • Robert Morrison
  • Whitney Harrington
  • Moses Gwamaka
  • Jonathan D Kurtis
  • Michal Fried
  • Patrick E Duffy

Abstract

Background: Severe malaria risk varies between individuals, and most of this variation remains unexplained. Here, we examined the hypothesis that cytokine profiles at birth reflect inter-individual differences that persist and influence malaria parasite density and disease severity throughout early childhood. Methods and Findings: Cytokine levels (TNF-α, IFN-γ, IL-1β, IL-4, IL-5, IL-6 and IL-10) were measured at birth (cord blood; N=783) and during subsequent routine follow-up visits (peripheral blood) for children enrolled between 2002 and 2006 into a birth cohort in Muheza, Tanzania. Children underwent blood smear and clinical assessments every 2-4 weeks, and at the time of any illness. Cord blood levels of all cytokines were positively correlated with each other (Spearman’s rank correlation). Cord levels of IL-1β and TNF-α (but not other cytokines) correlated with levels of the same cytokine measured at routine visits during early life (P

Suggested Citation

  • Edward Kabyemela & Bronner P Gonçalves & D Rebecca Prevots & Robert Morrison & Whitney Harrington & Moses Gwamaka & Jonathan D Kurtis & Michal Fried & Patrick E Duffy, 2013. "Cytokine Profiles at Birth Predict Malaria Severity during Infancy," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    • Handle: RePEc:plo:pone00:0077214
    DOI: 10.1371/journal.pone.0077214
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