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Cholesteryl Ester Transfer Protein Inhibitors in the Treatment of Dyslipidemia: A Systematic Review and Meta-Analysis

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  • Chuanwei Li
  • Wen Zhang
  • Faying Zhou
  • Caiyu Chen
  • Liang Zhou
  • Yafei Li
  • Ling Liu
  • Fang Pei
  • Hao Luo
  • Zhangxue Hu
  • Jing Cai
  • Chunyu Zeng

Abstract

Cholesteryl ester transfer protein (CETP) inhibitors are gaining substantial research interest for raising high density lipoprotein cholesterol levels. The aim of the research was to estimate the efficacy and safety of cholesteryl ester transfer protein inhibitors as novel lipid modifying drugs. Systematic searches of English literature for randomized controlled trials (RCT) were collected from MEDLINE, EBASE, CENTRAL and references listed in eligible studies. Two independent authors assessed the search results and only included the double-blind RCTs by using cholesteryl ester transfer protein inhibitors as exclusively or co-administrated with statin therapy irrespective of gender in enrolled adult subjects. Two independent authors extracted the data by using predefined data fields. Of 503 studies identified, 14 studies met the inclusion criteria, and 12 studies were included into the final meta-analysis. Our meta-analysis revealed that CETP inhibitors increased the HDL-c levels (n = 2826, p

Suggested Citation

  • Chuanwei Li & Wen Zhang & Faying Zhou & Caiyu Chen & Liang Zhou & Yafei Li & Ling Liu & Fang Pei & Hao Luo & Zhangxue Hu & Jing Cai & Chunyu Zeng, 2013. "Cholesteryl Ester Transfer Protein Inhibitors in the Treatment of Dyslipidemia: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0077049
    DOI: 10.1371/journal.pone.0077049
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