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Poor Prognosis of Phosphatase of Regenerating Liver 3 Expression in Gastric Cancer: A Meta-Analysis

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  • Liren Hu
  • Haiqing Luo
  • Wenjuan Wang
  • Hongjiao Li
  • Taiping He

Abstract

Background: Overexpression of phosphatase of regenerating liver 3 (PRL-3) has been implicated in gastric cancer (GC) metastasis. Epidemiological studies have evaluated the relationship between PRL-3 expression and prognosis in GC. However, results still remains controversial. In this study, a meta-analysis was performed to evaluate the association of PRL-3 expression with overall survival (OS) and clinicopathological characteristics. Methods: Literature databases were searched to identify eligible studies dated until April 2013. Summary hazard ratios (HRs) or odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to estimate the association. Results: A total of 1380 GC patients from six studies were included in the meta-analysis. Overall, the combined HR estimate for OS in a random-effect model was 1.89 (95% CI = 1.38–2.60; P

Suggested Citation

  • Liren Hu & Haiqing Luo & Wenjuan Wang & Hongjiao Li & Taiping He, 2013. "Poor Prognosis of Phosphatase of Regenerating Liver 3 Expression in Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0076927
    DOI: 10.1371/journal.pone.0076927
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