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Increased Risk of Developing Digestive Tract Cancer in Subjects Carrying the PLCE1 rs2274223 A>G Polymorphism: Evidence from a Meta-Analysis

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  • Xunlei Zhang
  • Yangmei Zhang
  • Dongying Gu
  • Chunxiang Cao
  • Qi Zhang
  • Zhi Xu
  • Yongling Gong
  • Jinfei Chen
  • Cuiju Tang

Abstract

Background: To date, the association between phospholipase C epsilon 1 (PLCE1) rs2274223 A>G and risk of digestive tract cancer (DTC) remains inconclusive. To derive a more precise estimation of the association, we conducted a meta-analysis on all eligible case–control studies involving 8281 cases and 10,532 controls. Methods: A comprehensive search was conducted to identify all eligible studies of PLCE1 rs2274223 polymorphism and digestive tract cancer risk. The pooled odds ratio (OR) and the 95% confidence interval (95% CI) were calculated using a fixed or random effect model. Heterogeneity, publication bias, and sensitivity analysis were also explored. Results: Overall, the PLCE1 rs2274223 A>G polymorphism was associated with risk of DTC in all genetic models (GA vs. AA: OR = 1.21, 95% CI = 1.14–1.29, P G polymorphism was significantly associated with increased risk of DTC, especially among Asian populations. Due to some minor limitations, our findings should be confirmed in further studies.

Suggested Citation

  • Xunlei Zhang & Yangmei Zhang & Dongying Gu & Chunxiang Cao & Qi Zhang & Zhi Xu & Yongling Gong & Jinfei Chen & Cuiju Tang, 2013. "Increased Risk of Developing Digestive Tract Cancer in Subjects Carrying the PLCE1 rs2274223 A>G Polymorphism: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-9, October.
    • Handle: RePEc:plo:pone00:0076425
    DOI: 10.1371/journal.pone.0076425
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