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Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C

Author

Listed:
  • Ángeles Ruiz-Extremera
  • José Antonio Muñoz-Gámez
  • Ana Abril-Molina
  • María Angustias Salmerón-Ruiz
  • Paloma Muñoz-de-Rueda
  • Esther José Pavón-Castillero
  • Rosa Quiles-Pérez
  • Ángel Carazo
  • Ana Gila
  • Sergio Manuel Jimenez-Ruiz
  • Jorge Casado
  • Ana Belén Martín
  • Laura Sanjuán-Núñez
  • Esther Ocete-Hita
  • Julián López Viota
  • Josefa León
  • Javier Salmerón

Abstract

This study analyses the evolution of liver disease in women with chronic hepatitis C during the third trimester of pregnancy and the post-partum period, as a natural model of immune modulation and reconstitution. Of the 122 mothers recruited to this study, 89 were HCV-RNA+ve/HIV-ve and 33 were HCV-RNA-ve/HIV-ve/HCVantibody+ve and all were tested during the third trimester of pregnancy, at delivery and post-delivery. The HCV-RNA+ve mothers were categorized as either Type-A (66%), with an increase in ALT levels in the post-partum period (>40 U/L; P

Suggested Citation

  • Ángeles Ruiz-Extremera & José Antonio Muñoz-Gámez & Ana Abril-Molina & María Angustias Salmerón-Ruiz & Paloma Muñoz-de-Rueda & Esther José Pavón-Castillero & Rosa Quiles-Pérez & Ángel Carazo & Ana Gil, 2013. "Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-9, October.
    • Handle: RePEc:plo:pone00:0075613
    DOI: 10.1371/journal.pone.0075613
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