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Suitability of Pharmacokinetic Models for Dynamic Contrast-Enhanced MRI of Abdominal Aortic Aneurysm Vessel Wall: A Comparison

Author

Listed:
  • V Lai Nguyen
  • M Eline Kooi
  • Walter H Backes
  • Raf H M van Hoof
  • Anne E C M Saris
  • Mirthe C J Wishaupt
  • Femke A M V I Hellenthal
  • Rob J van der Geest
  • Alfons G H Kessels
  • Geert Willem H Schurink
  • Tim Leiner

Abstract

Purpose: Increased microvascularization of the abdominal aortic aneurysm (AAA) vessel wall has been related to AAA progression and rupture. The aim of this study was to compare the suitability of three pharmacokinetic models to describe AAA vessel wall enhancement using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and Methods: Patients with AAA underwent DCE-MRI at 1.5 Tesla. The volume transfer constant (Ktrans), which reflects microvascular flow, permeability and surface area, was calculated by fitting the blood and aneurysm vessel wall gadolinium concentration curves. The relative fit errors, parameter uncertainties and parameter reproducibilities for the Patlak, Tofts and Extended Tofts model were compared to find the most suitable model. Scan-rescan reproducibility was assessed using the interclass correlation coefficient and coefficient of variation (CV). Further, the relationship between Ktrans and AAA size was investigated. Results: DCE-MRI examinations from thirty-nine patients (mean age±SD: 72±6 years; M/F: 35/4) with an mean AAA maximal diameter of 49±6 mm could be included for pharmacokinetic analysis. Relative fit uncertainties for Ktrans based on the Patlak model (17%) were significantly lower compared to the Tofts (37%) and Extended Tofts model (42%) (p

Suggested Citation

  • V Lai Nguyen & M Eline Kooi & Walter H Backes & Raf H M van Hoof & Anne E C M Saris & Mirthe C J Wishaupt & Femke A M V I Hellenthal & Rob J van der Geest & Alfons G H Kessels & Geert Willem H Schurin, 2013. "Suitability of Pharmacokinetic Models for Dynamic Contrast-Enhanced MRI of Abdominal Aortic Aneurysm Vessel Wall: A Comparison," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-7, October.
    • Handle: RePEc:plo:pone00:0075173
    DOI: 10.1371/journal.pone.0075173
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