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Glutathione S-Transferase T1, O1 and O2 Polymorphisms Are Associated with Survival in Muscle Invasive Bladder Cancer Patients

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Listed:
  • Tatjana I Djukic
  • Ana R Savic-Radojevic
  • Tatjana D Pekmezovic
  • Marija G Matic
  • Marija S Pljesa-Ercegovac
  • Vesna M Coric
  • Tanja M Radic
  • Sonja R Suvakov
  • Biljana N Krivic
  • Dejan P Dragicevic
  • Tatjana P Simic

Abstract

Objective: To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. Patients and Methods: A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival. Results: GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006). Conclusion: GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.

Suggested Citation

  • Tatjana I Djukic & Ana R Savic-Radojevic & Tatjana D Pekmezovic & Marija G Matic & Marija S Pljesa-Ercegovac & Vesna M Coric & Tanja M Radic & Sonja R Suvakov & Biljana N Krivic & Dejan P Dragicevic &, 2013. "Glutathione S-Transferase T1, O1 and O2 Polymorphisms Are Associated with Survival in Muscle Invasive Bladder Cancer Patients," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0074724
    DOI: 10.1371/journal.pone.0074724
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