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Prediabetes Is Associated with an Increased Risk of Testosterone Deficiency, Independent of Obesity and Metabolic Syndrome

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  • Chen-Hsun Ho
  • Hong-Jeng Yu
  • Chih-Yuan Wang
  • Fu-Shan Jaw
  • Ju-Ton Hsieh
  • Wan-Chung Liao
  • Yeong-Shiau Pu
  • Shih-Ping Liu

Abstract

Objective: The association between type 2 diabetes and low testosterone has been well recognized. However, testosterone levels in men with prediabetes have been rarely reported. We aimed to investigate whether prediabetes was associated with an increased risk of testosterone deficiency. Methods: This study included 1,306 men whose sex hormones was measured during a medical examination. Serum total testosterone and sex hormone-binding globulin were measured; free and bioavailable testosterone concentrations were calculated by Vermeulen’s formula. Prediabetes was defined by impaired fasting glucose (IFG), impaired postprandial glucose (IPG), or glycated hemoglobin (HbA1c) 5.7%-6.4%. Logistic regression was performed to obtain the odds ratios (OR) for subnormal total testosterone (

Suggested Citation

  • Chen-Hsun Ho & Hong-Jeng Yu & Chih-Yuan Wang & Fu-Shan Jaw & Ju-Ton Hsieh & Wan-Chung Liao & Yeong-Shiau Pu & Shih-Ping Liu, 2013. "Prediabetes Is Associated with an Increased Risk of Testosterone Deficiency, Independent of Obesity and Metabolic Syndrome," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
  • Handle: RePEc:plo:pone00:0074173
    DOI: 10.1371/journal.pone.0074173
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    Cited by:

    1. Sopiko Kandelaki & Keti Tsomaia & Salome Kordzaia & Salome Kordzaia & Dimitri Kordzaia & Manana Kakabadze, 2017. "Are Androgens Valuable in Management of Diabetes?," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 2(5), pages 91-94, July.

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