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Lack of Association between Hsa-miR-149 rs2292832 Polymorphism and Cancer Risk: A Meta-Analysis of 12 Studies

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  • Lei Xu
  • Xin Zhou
  • Man-Tang Qiu
  • Rong Yin
  • Ya-Qin Wu
  • Lin Xu

Abstract

Background: MicroRNAs (miRNAs) participate in various cellular processes such as cell growth, differentiation, cell death and play an important role in a variety of diseases, especially in cancer. Recently, a number of studies have investigated the association between single nucleotide polymorphisms (SNPs) on the hsa-miR-149 rs2292832 and susceptibility to cancer; however, the results remain inconclusive. Methodology/Principal Findings: We carried out a meta-analysis of 12 studies including 5937 cases and 6081 controls from PubMed to assess the association between the hsa-miR-149 rs2292832 and cancer risk by pooled odds ratios (ORs) and 95% confidence intervals (CIs). However, our results showed that genotype distribution of the hsa-miR-149 rs2292832 was not associated with cancer risk in all genetic models. Subgroup analysis by cancer type, ethnicity or study design showed no significant association either. Conclusion: Results of this meta-analysis suggest that the hsa-miR-149 rs2292832 polymorphism is not associated with cancer risk in spite of the potentially protective role of C allele in hepatocellular carcinoma and male gastric cancer.

Suggested Citation

  • Lei Xu & Xin Zhou & Man-Tang Qiu & Rong Yin & Ya-Qin Wu & Lin Xu, 2013. "Lack of Association between Hsa-miR-149 rs2292832 Polymorphism and Cancer Risk: A Meta-Analysis of 12 Studies," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    • Handle: RePEc:plo:pone00:0073762
    DOI: 10.1371/journal.pone.0073762
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    1. Ying Wang & Xiushan Zheng & Zhiyong Zhang & Jinfeng Zhou & Guohong Zhao & Jianjun Yang & Limin Xia & Rui Wang & Xiqiang Cai & Hao Hu & Cailin Zhu & Yongzhan Nie & Kaichun Wu & Dexin Zhang & Daiming Fa, 2012. "MicroRNA-149 Inhibits Proliferation and Cell Cycle Progression through the Targeting of ZBTB2 in Human Gastric Cancer," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-10, October.
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