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Poor Metabolizers at the Cytochrome P450 2C19 Loci Is at Increased Risk of Developing Cancer in Asian Populations

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  • Hong Wang
  • Kang Song
  • Zenggan Chen
  • Yanmin Yu

Abstract

Background: CYP2C19 encodes a member of the cytochrome P450 superfamily of enzymes, which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development of cancer. In the past decade, two common polymorphisms among CYP2C19 (CYP2C19*2 and CYP2C19*3) that are responsible for the poor metabolizers (PMs) phenotype in humans and cancer susceptibility have been investigated extensively; however, these studies have yielded contradictory results. Methods and Results: To investigate this inconsistency, we conducted a comprehensive meta-analysis of 11,554 cases and 16,592 controls from 30 case-control studies. Overall, the odds ratio (OR) of cancer was 1.52 [95% confidence interval (CI): 1.23–1.88, P

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  • Hong Wang & Kang Song & Zenggan Chen & Yanmin Yu, 2013. "Poor Metabolizers at the Cytochrome P450 2C19 Loci Is at Increased Risk of Developing Cancer in Asian Populations," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    • Handle: RePEc:plo:pone00:0073126
    DOI: 10.1371/journal.pone.0073126
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