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Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome

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  • Simone Bastrup-Birk
  • Mikkel-Ole Skjoedt
  • Lea Munthe-Fog
  • Jens J Strom
  • Ying Jie Ma
  • Peter Garred

Abstract

The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 levels and its use as a biomarker in patients with systemic inflammation, we developed a solid-phase enzyme-linked immunosorbent assay based on novel anti-PTX3 monoclonal antibodies detecting PTX3 with high sensitivity. The assay was applied on 261 consecutive patients admitted to an intensive care unit prospectively monitored with the systemic inflammatory response syndrome (SIRS). 100 blood donors were included as controls. PTX3 levels were elevated in patients (median = 71.3 ng/ml) compared with the controls (median = 0 ng/ml) (Mann-Whitney, p

Suggested Citation

  • Simone Bastrup-Birk & Mikkel-Ole Skjoedt & Lea Munthe-Fog & Jens J Strom & Ying Jie Ma & Peter Garred, 2013. "Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0073119
    DOI: 10.1371/journal.pone.0073119
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