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Psychiatric Illness and Intellectual Disability in the Prader–Willi Syndrome with Different Molecular Defects - A Meta Analysis

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  • Lin Yang
  • Guo-dong Zhan
  • Jun-jie Ding
  • Hui-jun Wang
  • Duan Ma
  • Guo-ying Huang
  • Wen-hao Zhou

Abstract

Background and Objectives: Several studies have suggested a difference in clinical features of intellectual ability and psychiatric illness in the Prader–Willi syndrome (PWS) with the 15q11-q13 paternal deletion and maternal uniparental disomy (mUPD). Our objective was to appraise evidence on this association through a meta-analysis. Methods: The electronic records PubMed and EMBASE from 1956 to 2012 were extracted for meta-analysis. Meta-analyses were performed by using fixed effect model. Mean difference, odds ratio, and 95% confidence interval were calculated. Results: We retrieved a total of 744 PWS cases from 13 studies. These include 423 cases with paternal 15q11-q13 deletions and 318 cases of mUPD. Compare to the PWS cases with mUPD, PWS patients with the paternal 15q11-q13 deletion associated with significantly lower full scale IQ (FSIQ) [mean difference (MD), -2.69; 95%CI, -4.86 to -0.52; p=0.02] and verbal IQ (VIQ) (MD, -7.5; 95%CI, -9.75 to -5.26; p

Suggested Citation

  • Lin Yang & Guo-dong Zhan & Jun-jie Ding & Hui-jun Wang & Duan Ma & Guo-ying Huang & Wen-hao Zhou, 2013. "Psychiatric Illness and Intellectual Disability in the Prader–Willi Syndrome with Different Molecular Defects - A Meta Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    • Handle: RePEc:plo:pone00:0072640
    DOI: 10.1371/journal.pone.0072640
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