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The TLR9 Gene Polymorphisms and the Risk of Cancer: Evidence from a Meta-Analysis

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  • LuShun Zhang
  • HaoJie Qin
  • Xuan Guan
  • Kui Zhang
  • ZhiRong Liu

Abstract

Background: Growing studies have revealed the association between polymorphisms in the Toll-like receptor 9 (TLR9) and susceptibility to cancer, however, the results remained inconsistent. Methodology/Principal Findings: To assess the effect of three selected SNPs (rs352140, rs5743836 and rs187084) in TLR9 on cancer, we performed a meta-analysis based on 11 case-control studies, including a total of 6,585 cancer cases and 7,506 controls. Summary odds ratios (OR) and corresponding 95% confidence intervals (CIs) for polymorphisms in TLR9 and cancer risk were estimated. Our meta-analysis indicated that rs352140 was associated with an increased cancer risk, especially in Caucasian. However, no significantly increased cancer risk was detected to be associated with rs187084 and rs5743836 either the overall or subgroup estimation. Conclusions: These meta-analysis results indicate that polymorphisms in TLR9 may play a role in cancer development.

Suggested Citation

  • LuShun Zhang & HaoJie Qin & Xuan Guan & Kui Zhang & ZhiRong Liu, 2013. "The TLR9 Gene Polymorphisms and the Risk of Cancer: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-7, August.
    • Handle: RePEc:plo:pone00:0071785
    DOI: 10.1371/journal.pone.0071785
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    1. Jing Guo & Mingjuan Jin & Mingwu Zhang & Kun Chen, 2012. "A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
    2. Man-Tang Qiu & Jing-Wen Hu & Xiang-Xiang Ding & Xin Yang & Zhi Zhang & Rong Yin & Lin Xu, 2012. "Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
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