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Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules

Author

Listed:
  • Hong-Yan Zhang
  • Yu-Ru Liu
  • Chao Ji
  • Wei Li
  • Shuo-Xing Dou
  • Ping Xie
  • Wei-Chi Wang
  • Ling-Yun Zhang
  • Peng-Ye Wang

Abstract

The interactions of DNA with oxaliplatin (Pt(R,R-DACH)) or its enantiomer (Pt(S,S-DACH)) were investigated using magnetic tweezers and atomic force microscope. In the process of DNA condensation induced by Pt-DACH, only diadducts and micro-loops are formed at low Pt-DACH concentrations, while at high Pt-DACH concentrations, besides the diadducts and micro-loops, long-range cross-links are also formed. The diadduct formation rate of Pt(R,R-DACH) is higher than that of Pt(S,S-DACH). However, the proportions of micro-loops and long-range cross-links for Pt(S,S-DACH) are higher than those for Pt(R,R-DACH). We propose a model to explain these differences between the effect of Pt(R,R-DACH) and that of Pt(S,S-DACH) on DNA condensation. The study has strong implications for the understanding of the effect of chirality on the interaction between Pt-DACH and DNA and the kinetics of DNA condensation induced by platinum complexes.

Suggested Citation

  • Hong-Yan Zhang & Yu-Ru Liu & Chao Ji & Wei Li & Shuo-Xing Dou & Ping Xie & Wei-Chi Wang & Ling-Yun Zhang & Peng-Ye Wang, 2013. "Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0071556
    DOI: 10.1371/journal.pone.0071556
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