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Hormone Replacement Therapy in Females Can Decrease the Risk of Lung Cancer: A Meta-Analysis

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  • Yanwen Yao
  • Xiaoling Gu
  • Juehua Zhu
  • Dongmei Yuan
  • Yong Song

Abstract

The purpose of the present meta-analysis was to determine the relationship between hormone replacement therapy (HRT) and lung cancer risk in females. Publications were reviewed and obtained through a PubMed, EMBASE database and Cochrane Library literature search up to May, 2012. The detailed numbers of patients in different groups, odd ratios (ORs) and corresponding 95% confidence intervals (CIs) were collected and estimated using a random-effects model. Twenty five studies entered into the meta-analysis. The total number of participates and lung cancer patients was 656,403 and 11,442, respectively. The OR of all 25 studies was 0.91 (95%CI = 0.83 to 0.99) and P value was 0.033. In stratified analyses, the positive association between HRT use and decreased lung cancer risk was also found in the patients with BMI

Suggested Citation

  • Yanwen Yao & Xiaoling Gu & Juehua Zhu & Dongmei Yuan & Yong Song, 2013. "Hormone Replacement Therapy in Females Can Decrease the Risk of Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0071236
    DOI: 10.1371/journal.pone.0071236
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