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The Prognostic Value of SOX2 Expression in Non-Small Cell Lung Cancer: A Meta-Analysis

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  • Yansu Chen
  • Yefei Huang
  • Yulin Huang
  • Junjie Chen
  • Shouyu Wang
  • Jianwei Zhou

Abstract

Objective: To investigate the association of SOX2 expression in tumor with clinicopathological features and survival of non-small-cell lung carcinoma (NSCLC) patients. Methods: Publications assessing the clinicopathological characteristics and prognostic significance of SOX2 in NSCLC were identified up to May 2013. A meta-analysis of eligible studies was performed using standard statistical methods to clarify the association between SOX2 expression and these clinical parameters. Results: A total of eight studies met the inclusion criteria. Analysis of these data showed that SOX2 expression was positively associated with squamous histology, (pooled OR = 5.26, 95% CI: 1.08–25.6, P = 0.040). Simultaneously, we also found that SOX2 expression was positively associated with overall survival (pooled HR = 0.65, 95% CI: 0.47–0.89, P = 0.007, random-effect). Conclusions: SOX2 expression in tumor is a candidate positive prognostic biomarker for NSCLC patients.

Suggested Citation

  • Yansu Chen & Yefei Huang & Yulin Huang & Junjie Chen & Shouyu Wang & Jianwei Zhou, 2013. "The Prognostic Value of SOX2 Expression in Non-Small Cell Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-6, August.
    • Handle: RePEc:plo:pone00:0071140
    DOI: 10.1371/journal.pone.0071140
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