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Anthropometric Measures and Physical Activity and the Risk of Lung Cancer in Never-Smokers: A Prospective Cohort Study

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  • Tram Kim Lam
  • Steve C Moore
  • Louise A Brinton
  • Llewellyn Smith
  • Albert R Hollenbeck
  • Gretchen L Gierach
  • Neal D Freedman

Abstract

Worldwide, lung cancer in never-smokers is ranked the seventh most common cause of cancer death; however, the etiology of lung cancer in never-smokers is unclear. We investigated associations for body mass index (BMI) at various ages, waist circumference, hip circumference, and physical activity with lung cancer in 158,415 never-smokers of the NIH-AARP Diet and Health Study. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated from Cox proportional hazards models. Over 11 years of follow-up, 532 lung cancer cases occurred. The risk estimate for obese (BMI≥30 kg/m2) participants at baseline was 1.21 (95%CI = 0.95–1.53) relative to those with a normal BMI between 18.5≤BMI

Suggested Citation

  • Tram Kim Lam & Steve C Moore & Louise A Brinton & Llewellyn Smith & Albert R Hollenbeck & Gretchen L Gierach & Neal D Freedman, 2013. "Anthropometric Measures and Physical Activity and the Risk of Lung Cancer in Never-Smokers: A Prospective Cohort Study," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0070672
    DOI: 10.1371/journal.pone.0070672
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