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XRCC3 Thr241Met Polymorphism and Clinical Outcomes of NSCLC Patients Receiving Platinum-Based Chemotherapy: A Systematic Review and Meta-Analysis

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  • Xiao-yong Shen
  • Fan-zhen Lu
  • Yun Wu
  • Li-ting Zhao
  • Zhi-feng Lin

Abstract

Introduction: X-ray repair cross-complementing protein 3 (XRCC3) is an essential gene involved in the double-strand break repair pathway. Published evidence has shown controversial results about the relationship between XRCC3 Thr241Met polymorphism and clinical outcomes of non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. Methods: A systematic review and meta-analysis was performed to evaluate the predictive value of XRCC3 Thr241Met polymorphism on clinical outcomes of advanced NSCLC receiving platinum-based chemotherapy. Response to chemotherapy, overall survival (OS) and progression-free survival (PFS) were analyzed. Results: A number of 11 eligible studies were identified according to the inclusion criteria. Carriers of the variant XRCC3 241Met allele were significantly associated with good response to platinum-based chemotherapy (ThrMet/MetMet vs. ThrThr: OR = 1.509, 95% CI: 1.099–2.072, Pheterogeneity = 0.618). The XRCC3 Thr241Met polymorphism was not associated with OS (MetMet vs. ThrThr, HR = 0.939, 95% CI:0.651–1.356, Pheterogeneity = 0.112) or PFS (MetMet vs. ThrThr, HR = 0.960, 95% CI: 0.539–1.710, Pheterogeneity = 0.198). Additionally, no evidence of publication bias was observed. Conclusions: This systematic review and meta-analysis shows that carriers of the XRCC3 241Met allele are associated with good response to platinum-based chemotherapy in advanced NSCLC, while the XRCC3 Thr241Met polymorphism is not associated with OS or PFS.

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  • Xiao-yong Shen & Fan-zhen Lu & Yun Wu & Li-ting Zhao & Zhi-feng Lin, 2013. "XRCC3 Thr241Met Polymorphism and Clinical Outcomes of NSCLC Patients Receiving Platinum-Based Chemotherapy: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-7, August.
    • Handle: RePEc:plo:pone00:0069553
    DOI: 10.1371/journal.pone.0069553
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    References listed on IDEAS

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    1. Hang Zhou & Chao Zeng & Yang Wei & Jin Zhou & Wenxiu Yao, 2013. "Duration of Chemotherapy for Small Cell Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-9, August.
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    Cited by:

    1. Yu-Zhe Song & Fu-Jun Han & Min Liu & Cheng-Cheng Xia & Wei-Yan Shi & Li-Hua Dong, 2015. "Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-17, June.

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