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Minimal Residual Disease-Based Risk Stratification in Chinese Childhood Acute Lymphoblastic Leukemia by Flow Cytometry and Plasma DNA Quantitative Polymerase Chain Reaction

Author

Listed:
  • Suk Hang Cheng
  • Kin Mang Lau
  • Chi Kong Li
  • Natalie P H Chan
  • Rosalina K L Ip
  • Chi Keung Cheng
  • Vincent Lee
  • Matthew M K Shing
  • Alex W K Leung
  • Shau Yin Ha
  • Daniel K L Cheuk
  • Anselm C W Lee
  • Chak Ho Li
  • Chung Wing Luk
  • Siu Cheung Ling
  • Ondrej Hrusak
  • Ester Mejstrikova
  • Yonna Leung
  • Margaret H L Ng

Abstract

Minimal residual disease, or MRD, is an important prognostic indicator in childhood acute lymphoblastic leukemia. In ALL-IC-BFM 2002 study, we employed a standardized method of flow cytometry MRD monitoring for multiple centers internationally using uniformed gating, and determined the relevant MRD-based risk stratification strategies in our local patient cohort. We also evaluated a novel method of PCR MRD quantitation using peripheral blood plasma. For the bone marrow flow MRD study, patients could be stratified into 3 risk groups according to MRD level using a single time-point at day-15 (Model I) (I-A: 10%), or using two time-points at day-15 and day-33 (Model II) (II-A: day-15

Suggested Citation

  • Suk Hang Cheng & Kin Mang Lau & Chi Kong Li & Natalie P H Chan & Rosalina K L Ip & Chi Keung Cheng & Vincent Lee & Matthew M K Shing & Alex W K Leung & Shau Yin Ha & Daniel K L Cheuk & Anselm C W Lee , 2013. "Minimal Residual Disease-Based Risk Stratification in Chinese Childhood Acute Lymphoblastic Leukemia by Flow Cytometry and Plasma DNA Quantitative Polymerase Chain Reaction," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0069467
    DOI: 10.1371/journal.pone.0069467
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