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Overexpression of High Mobility Group A1 Protein in Human Uveal Melanomas: Implication for Prognosis

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  • Yi Qu
  • Yupeng Wang
  • Jinlan Ma
  • Yue Zhang
  • Nana Meng
  • Hao Li
  • Yan Wang
  • Wenbin Wei

Abstract

There is increasing evidence that the high mobility group A1 (HMGA1) protein, which functions as a transcriptional master regulator, plays critical roles in tumor progression. We evaluated HMGA1 expression in 89 primary uveal melanomas (UM) by immunohistochemistry to determine the clinicopathological and prognostic value of HMGA1 in UM after adjusting for other prognostic variables. Nuclear expression of HMGA1 was detected in 44% UMs. High expression levels of HMGA1 were more frequent in UMs with high levels of epithelioid cell pattern, mitoses count, and Ki67 labeling index (P = 0.025, P

Suggested Citation

  • Yi Qu & Yupeng Wang & Jinlan Ma & Yue Zhang & Nana Meng & Hao Li & Yan Wang & Wenbin Wei, 2013. "Overexpression of High Mobility Group A1 Protein in Human Uveal Melanomas: Implication for Prognosis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-7, July.
    • Handle: RePEc:plo:pone00:0068724
    DOI: 10.1371/journal.pone.0068724
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