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The Correlation Analysis of Two Common Polymorphisms in STAT6 Gene and the Risk of Asthma: A Meta-Analysis

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  • Li Zhu
  • Qingqing Zhu
  • Xinlin Zhang
  • Hongwei Wang

Abstract

Background: Several studies have reported that the GT dinucleotide repeat length polymorphism and the G2964A polymorphism in signal transducer and activator of transcriptional factor 6 gene are associated with asthma susceptibility, but others have conflicting results. Our meta-analysis aimed to elucidate the emerging paradigms. Methods: We searched PUBMED, EMBASE, ISI web of knowledge, Chinese National Knowledge Infrastructure, and Wanfang databases. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the strength of association. We applied Bonferroni step-down and Benjamini-Hochberg step-up methods to adjust the values for multiple comparisons. Results: A total of 12 individual studies in 11 articles were included in the meta-analysis. For GT repeat polymorphism, the S allele had approximately 45% increased risk of asthma (S vs. L: OR = 1.45, 95% CI = 1.22–1.71, PUNCORRECTED

Suggested Citation

  • Li Zhu & Qingqing Zhu & Xinlin Zhang & Hongwei Wang, 2013. "The Correlation Analysis of Two Common Polymorphisms in STAT6 Gene and the Risk of Asthma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
    • Handle: RePEc:plo:pone00:0067657
    DOI: 10.1371/journal.pone.0067657
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