Author
Listed:
- Giedre Gefenaite
- Margot Tacken
- Jens Bos
- Irina Stirbu-Wagner
- Joke C Korevaar
- Ronald P Stolk
- Bert Wolters
- Marc Bijl
- Maarten J Postma
- Jan Wilschut
- Kristin L Nichol
- Eelko Hak
Abstract
Introduction: Because of variability in published A(H1N1)pdm09 influenza vaccine effectiveness estimates, we conducted a study in the adults belonging to the risk groups to assess the A(H1N1)pdm09 MF59-adjuvanted influenza vaccine effectiveness. Methods: VE against influenza and/or pneumonia was assessed in the cohort study (n>25000), and vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza was assessed in a matched case-control study (16 pairs). Odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated by using multivariate logistic regression; vaccine effectiveness was estimated as (1-odds ratio)*100%. Results: Vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia was 98% (84–100%) and 33% (2–54%) respectively. The vaccine did not prevent influenza and/or pneumonia in 18–59 years old subjects, and was 49% (16–69%) effective in 60 years and older subjects. Conclusions: Even though we cannot entirely rule out that selection bias, residual confounding and/or cross-protection has played a role, the present results indicate that the MF59-adjuvanted A(H1N1)pdm09 influenza vaccine has been effective in preventing laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia, the latter notably in 60 years and older subjects.
Suggested Citation
Giedre Gefenaite & Margot Tacken & Jens Bos & Irina Stirbu-Wagner & Joke C Korevaar & Ronald P Stolk & Bert Wolters & Marc Bijl & Maarten J Postma & Jan Wilschut & Kristin L Nichol & Eelko Hak, 2013.
"Effectiveness of A(H1N1)pdm09 Influenza Vaccine in Adults Recommended for Annual Influenza Vaccination,"
PLOS ONE, Public Library of Science, vol. 8(6), pages 1-6, June.
Handle:
RePEc:plo:pone00:0066125
DOI: 10.1371/journal.pone.0066125
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