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The SEPS1 G-105A Polymorphism Is Associated with Risk of Spontaneous Preterm Birth in a Chinese Population

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  • Yan Wang
  • Xiao Yang
  • Yong Zheng
  • Zhi-Hao Wu
  • Xiao-Ai Zhang
  • Qiu-Ping Li
  • Xi-Yu He
  • Chun-Zhi Wang
  • Zhi-Chun Feng

Abstract

Inflammation plays an important role in the etiology and pathophysiology of spontaneous preterm birth (SPTB), and selenoprotein S (SEPS1) is involved in regulating the inflammatory response. Recently the G-105A promoter polymorphism in SEPS1 was shown to increase pro-inflammatory cytokine expression. We examined whether this functional polymorphism was related to the risk of SPTB in a Chinese population. We also examined the impact of premature rupture of membranes (PROM) on susceptibility to SPTB. The SEPS1 G-105A polymorphism was genotyped in 569 preterm singleton neonates and 673 term neonates by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. χ2 tests and logistic regression analyses were used to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs). We observed that, compared with the GG genotype, –105A positive genotypes (GA + AA genotypes) were associated with significantly increased susceptibility to SPTB (adjusted OR, 1.87; 95% CI, 1.36–2.57; P

Suggested Citation

  • Yan Wang & Xiao Yang & Yong Zheng & Zhi-Hao Wu & Xiao-Ai Zhang & Qiu-Ping Li & Xi-Yu He & Chun-Zhi Wang & Zhi-Chun Feng, 2013. "The SEPS1 G-105A Polymorphism Is Associated with Risk of Spontaneous Preterm Birth in a Chinese Population," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0065657
    DOI: 10.1371/journal.pone.0065657
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    1. Yihong Ye & Yoko Shibata & Chi Yun & David Ron & Tom A. Rapoport, 2004. "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol," Nature, Nature, vol. 429(6994), pages 841-847, June.
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