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Quantitative Assessment of the Association between rs2046210 at 6q25.1 and Breast Cancer Risk

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  • Xi Wu
  • Qing-Qing Xu
  • Liang Guo
  • Chuan-Ting Yu
  • Yu-Yu Xiong
  • Zhi-Yun Wei
  • Ran Huo
  • Sheng-Tian Li
  • Lu Shen
  • Jia-Min Niu
  • Lu Liu
  • Yi Lin
  • Lin He
  • Sheng-Ying Qin

Abstract

Genome-wide association studies (GWAS) have identified several genetic susceptibility loci for breast cancer (BC). One of them, conducted among Chinese women, found an association of rs2046210 at 6q25.1 with the risk of BC recently. Since then, numerous association studies have been carried out to investigate the relationship between this polymorphism and BC risk in various populations. However, these have yielded contradictory results. We therefore performed a meta-analysis to clarify this inconsistency. Overall, a total of 235003 subjects based on 13 studies were included in our study. Significantly increased BC risk was detected in the pooled analysis [allele contrast: OR = 1.13, 95%CI = 1.10–1.17, P(Z)

Suggested Citation

  • Xi Wu & Qing-Qing Xu & Liang Guo & Chuan-Ting Yu & Yu-Yu Xiong & Zhi-Yun Wei & Ran Huo & Sheng-Tian Li & Lu Shen & Jia-Min Niu & Lu Liu & Yi Lin & Lin He & Sheng-Ying Qin, 2013. "Quantitative Assessment of the Association between rs2046210 at 6q25.1 and Breast Cancer Risk," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0065206
    DOI: 10.1371/journal.pone.0065206
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