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The Genetic Variant on Chromosome 10p14 Is Associated with Risk of Colorectal Cancer: Results from a Case-Control Study and a Meta-Analysis

Author

Listed:
  • Qin Qin
  • Li Liu
  • Rong Zhong
  • Li Zou
  • Jieyun Yin
  • BeiBei Zhu
  • BeiBei Cao
  • Wei Chen
  • Jigui Chen
  • Xiaorong Li
  • Tingting Li
  • Xuzai Lu
  • Jiao Lou
  • Juntao Ke
  • Sheng Wei
  • Xiaoping Miao
  • Shaofa Nie

Abstract

Background: A common single nucleotide polymorphism (SNP), rs10795668, located at 10p14, was first identified to be significantly associated with risk of colorectal cancer (CRC) by a genome-wide association study (GWAS) in 2008; however, another GWAS and following replication studies yielded conflicting results. Methods: We conducted a case-control study of 470 cases and 475 controls in a Chinese population and then performed a meta-analysis, integrating the current study and 9 publications to evaluate the association between rs10795668 and CRC risk. Heterogeneity among studies and publication bias were assessed by the χ2-based Q statistic test and Egger's test, respectively. Results: In the case-control study, significant association between the SNP and CRC risk was observed, with per-A-allele OR of 0.71 (95%CI: 0.54–0.94, P = 0.017). The following meta-analysis further confirmed the significant association, with per-A-allele OR of 0.91 (95%CI: 0.89–0.93, Pheterogeneity>0.05) in European population and 0.86 (95%CI: 0.78–0.96, Pheterogeneity

Suggested Citation

  • Qin Qin & Li Liu & Rong Zhong & Li Zou & Jieyun Yin & BeiBei Zhu & BeiBei Cao & Wei Chen & Jigui Chen & Xiaorong Li & Tingting Li & Xuzai Lu & Jiao Lou & Juntao Ke & Sheng Wei & Xiaoping Miao & Shaofa, 2013. "The Genetic Variant on Chromosome 10p14 Is Associated with Risk of Colorectal Cancer: Results from a Case-Control Study and a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-9, May.
    • Handle: RePEc:plo:pone00:0064310
    DOI: 10.1371/journal.pone.0064310
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