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Comparison of Global Gene Expression of Gastric Cardia and Noncardia Cancers from a High-Risk Population in China

Author

Listed:
  • Gangshi Wang
  • Nan Hu
  • Howard H Yang
  • Lemin Wang
  • Hua Su
  • Chaoyu Wang
  • Robert Clifford
  • Erica M Dawsey
  • Jian-Min Li
  • Ti Ding
  • Xiao-You Han
  • Carol Giffen
  • Alisa M Goldstein
  • Philip R Taylor
  • Maxwell P Lee

Abstract

Objective: To profile RNA expression in gastric cancer by anatomic subsites as an initial step in identifying molecular subtypes and providing targets for early detection and therapy. Methods: We performed transcriptome analysis using the Affymetrix GeneChip U133A in gastric cardia adenocarcinomas (n = 62) and gastric noncardia adenocarcinomas (n = 72) and their matched normal tissues from patients in Shanxi Province, and validated selected dysregulated genes with additional RNA studies. Expression of dysregulated genes was also related to survival of cases. Results: Principal Component Analysis showed that samples clustered by tumor vs. normal, anatomic location, and histopathologic features. Paired t-tests of tumor/normal tissues identified 511 genes whose expression was dysregulated (P

Suggested Citation

  • Gangshi Wang & Nan Hu & Howard H Yang & Lemin Wang & Hua Su & Chaoyu Wang & Robert Clifford & Erica M Dawsey & Jian-Min Li & Ti Ding & Xiao-You Han & Carol Giffen & Alisa M Goldstein & Philip R Taylor, 2013. "Comparison of Global Gene Expression of Gastric Cardia and Noncardia Cancers from a High-Risk Population in China," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0063826
    DOI: 10.1371/journal.pone.0063826
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